It has been used for more than 200 years as a mild relaxant and as a therapy for anxiety, nervous tension, and convulsions. Studies show American skullcap has significant antioxidant effects, and may help protect against neurological disorders, such as Alzheimer's disease, Parkinson's disease, anxiety, and depression. There's even some evidence to suggest that American skullcap may inhibit food allergic response. cited from here
- High doses of the tincture may cause giddiness, stupor, mental confusion, twitching, irregular heartbeat, and seizures.
- American skullcap should not be used during pregnancy and breastfeeding.